Gpam Gene Summary [Rat]
Enables glycerol-3-phosphate O-acyltransferase activity. Involved in several processes, including cellular response to insulin stimulus; glycerolipid biosynthetic process; and positive regulation of triglyceride biosynthetic process. Located in mitochondrial outer membrane. Biomarker of metabolic dysfunction-associated steatotic liver disease; nephrotic syndrome; and obesity. Orthologous to human GPAM (glycerol-3-phosphate acyltransferase, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpam |
| Official Name | glycerol-3-phosphate acyltransferase, mitochondrial [Source:RGD Symbol;Acc:61847] |
| Ensembl ID | ENSRNOG00000015124 |
| Bio databases IDs | |
| Aliases | glycerol-3-phosphate acyltransferase, mitochondrial |
| Synonyms | glycerol-3-phosphate acyltransferase, mitochondrial, Glycerol-phosphate acyltransferase, GPAT, GPAT-1, Gpat3, KIAA1560, LOC101927600, MGPAT, Mtgat, mtGPAT, Mtgpat1, P90 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gpam often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- glycerol-3-phosphate O-acyltransferase
- enzyme
- protein binding
- Acyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- Huntington disease
- liver disease
- metabolic syndrome X
- weight gain
- hyperinsulinism
- Ullrich congenital muscular dystrophy
- microvesicular hepatic steatosis
- keratocystic odontogenic tumor
regulates
- cholesterol
- triacylglycerol
- Scd1
- lipid
- AKT
- cytokine
- NFkB (complex)
- D-glucose
- MTOR
- glycerophospholipid
role in cell
- proliferation
- phosphorylation in
- production in
- accumulation in
- binding in
- fusion
- signaling in
- fusion in
- incorporation in
- oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- outer membranes
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial membrane
- mitochondrial outer membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gpam gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerol-3-phosphate metabolic process
- fatty acid homeostasis
- diacylglycerol biosynthetic process
- phospholipid biosynthetic process
- phosphatidylglycerol biosynthetic process
- positive regulation of activated T cell proliferation
- phospholipid homeostasis
- fatty acid metabolic process
- positive regulation of multicellular organism growth
- phosphatidic acid biosynthetic process
- acyl-CoA metabolic process
- activation-induced cell death of T cells
- response to glucose stimulus
- triglyceride biosynthetic process
- negative regulation of activation-induced cell death of T cells
- defense response to virus
- CDP-diacylglycerol biosynthetic process
- regulation of cytokine production
- activated T cell proliferation
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- mitochondrial outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- glycerol-3-phosphate O-acyltransferase activity