Ppp2r2b Gene Summary [Rat]
Predicted to enable protein phosphatase regulator activity. Involved in several processes, including mitochondrion organization; positive regulation of neuron apoptotic process; and protein targeting to mitochondrion. Located in mitochondrial outer membrane. Part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; brain disease; breast cancer; and spinocerebellar ataxia type 12. Orthologous to human PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp2r2b |
| Official Name | protein phosphatase 2, regulatory subunit B, beta [Source:RGD Symbol;Acc:631441] |
| Ensembl ID | ENSRNOG00000018851 |
| Bio databases IDs | |
| Aliases | protein phosphatase 2, regulatory subunit B, beta |
| Synonyms | 2900026H06RIK, 6330404L05Rik, AU018728, B55BETA, E130009M08RIK, LOC108167376, pp2A, PP2AB55BETA, PP2ABBETA, Pp2a B-β, PP2A-PR55B, PP2APR55BETA, PP2R2B, PPPR2B2, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55-BETA, PR55-β, protein phosphatase 2 regulatory subunit Bbeta, protein phosphatase 2, regulatory subunit B, beta, protein PHOSPHATASE 2, REGULATORY subunit B, beta isoform, protein phosphatase 2, regulatory subunit B, β, protein PHOSPHATASE 2, REGULATORY subunit B, β isoform, SCA12 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppp2r2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- phosphoprotein phosphatase
- phosphatase
- protein phosphatase regulator
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the Ppp2r2b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Autophagy
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Ceramide Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Cyclins and Cell Cycle Regulation
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Mitotic Roles of Polo-Like Kinase
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of eIF4 and p70S6K Signaling
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Telomerase Signaling
- Tight Junction Signaling
- WNT/β-catenin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- major depression
- neoplasia
- liver cancer
- pervasive developmental disorder
- breast cancer
- Takayasu arteritis
- spinocerebellar ataxia 12
- early missed abortion
- chickenpox
role in cell
- apoptosis
- survival
- proliferation
- cell cycle progression
- dephosphorylation in
- binding in
- degradation in
- stabilization in
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial outer membrane
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppp2r2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- mitochondrion
- cytosol
- mitochondrial outer membrane
- protein phosphatase type 2A complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein phosphatase regulator activity