Ep400 Gene Summary [Rat]
Enables chromatin binding activity and protein antigen binding activity. Predicted to be involved in DNA repair; positive regulation of double-strand break repair via homologous recombination; and regulation of cell cycle. Predicted to be located in nuclear speck. Predicted to be part of NuA4 histone acetyltransferase complex; Swr1 complex; and nucleosome. Orthologous to several human genes including EP400 (E1A binding protein p400). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ep400 |
| Official Name | E1A binding protein p400 [Source:RGD Symbol;Acc:1304733] |
| Ensembl ID | ENSRNOG00000037483 |
| Bio databases IDs | |
| Aliases | E1A binding protein p400 |
| Synonyms | 1700020J09Rik, CAGH32, E1A binding protein p400, mDomino, mKIAA1498, NHCP p400, P400, TNRC12 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ep400 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- domain in helicases and associated with SANT domains
- SNF2-related domain
- helicase superfamily c-terminal domain
- antigen binding
- chromatin binding
- protein binding
- HSA domain
- Helicase conserved C-terminal domain
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
- E1A-binding protein p400, N-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- anemia
- metabolic syndrome X
role in cell
- quantity
- expression in
- activation in
- growth
- morphology
- apoptosis
- colony formation
- G1 phase
- S phase
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleosomes
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ep400 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- chromatin remodeling
- regulation of double-strand break repair
- positive regulation of transcription, DNA-dependent
- regulation of apoptotic process
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- NuA4 histone acetyltransferase complex
- nuclear speck
- Swr1 complex
- nucleosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA binding
- protein binding
- helicase activity
- chromatin binding
- hydrolase activity