Aspnl1 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Involved in response to fluoride. Located in cell projection. Human ortholog(s) of this gene implicated in ankylosing spondylitis; degenerative disc disease; and osteoarthritis. Orthologous to human ASPN (asporin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aspnl1 |
| Official Name | asporin-like 1 [Source:RGD Symbol;Acc:9278606] |
| Ensembl ID | ENSRNOG00000015410 |
| Bio databases IDs | |
| Aliases | asporin-like 1 |
| Synonyms | 4631401G09Rik, Aspnl1, Asporin, OS3, PLAP-1, SLRR1C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aspnl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- calcium ion binding
- Leucine rich repeat
- protein binding
- Leucine rich repeat N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- gastric cancer
- gastric adenocarcinoma
- neoplasia
- colorectal neoplasm
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- gastric epithelial cancer
- adenoma formation
- organismal death
role in cell
- differentiation
- apoptosis
- activation in
- binding in
- number
- morphology
- abnormal morphology
- colony formation by
- mineralization
- diameter
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- extracellular matrix
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aspnl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of tooth mineralization
- bone mineralization
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- cell projection
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- extracellular matrix structural constituent conferring compression resistance