Bcat1 Gene Summary [Rat]
Enables branched-chain-amino-acid transaminase activity and identical protein binding activity. Predicted to be involved in L-leucine biosynthetic process and L-valine biosynthetic process. Predicted to act upstream of or within branched-chain amino acid catabolic process. Is active in cytoplasm. Orthologous to human BCAT1 (branched chain amino acid transaminase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcat1 |
| Official Name | branched chain amino acid transaminase 1 [Source:RGD Symbol;Acc:2195] |
| Ensembl ID | ENSRNOG00000015514 |
| Bio databases IDs | |
| Aliases | branched chain amino acid transaminase 1 |
| Synonyms | BCATC, BCT1, branched chain amino acid transaminase 1, branched chain aminotransferase 1, cytosolic, ECA39, MECA39, PNAS121, PP18 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bcat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thyroid-hormone transaminase
- PLPDE_IV
- Amino-transferase class IV
- branched-chain-amino-acid transaminase
- enzyme
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Bcat1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- diabetes mellitus
- metastasis
- septic shock
- blast crisis phase chronic myeloid leukemia
- nonalcoholic fatty liver disease
- breast carcinoma
- de novo acute myeloid leukemia
- organismal death
- lung adenocarcinoma formation
role in cell
- expression in
- growth
- proliferation
- phosphorylation in
- migration
- production in
- differentiation
- accumulation
- invasion
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bcat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- valine biosynthetic process
- G1/S transition of mitotic cell cycle
- leucine biosynthetic process
- lipid metabolic process
- branched chain family amino acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- L-leucine transaminase activity
- L-valine transaminase activity
- L-leucine:2-oxoglutarate aminotransferase activity
- branched-chain-amino-acid transaminase activity
- L-isoleucine transaminase activity