Ppp2r5d Gene Summary [Rat]

Predicted to enable protein phosphatase activator activity. Involved in negative regulation of peptidyl-threonine phosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 35. Orthologous to human PPP2R5D (protein phosphatase 2 regulatory subunit B'delta). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Ppp2r5d
Official Name
protein phosphatase 2, regulatory subunit B', delta [Source:RGD Symbol;Acc:1306666]
Ensembl ID
ENSRNOG00000016849
Bio databases IDs NCBI: 363193 Ensembl: ENSRNOG00000016849
Aliases protein phosphatase 2, regulatory subunit B', delta
Synonyms B56D, B56delta, B'delta, B'δ, HJS1, LOC100909464, MRD35, PP2A B delta, PP2A B' delta, PP2A B δ, PP2A B' δ, protein phosphatase 2 regulatory subunit B'delta, protein phosphatase 2, regulatory subunit B', delta, protein phosphatase 2 regulatory subunit B'δ, protein phosphatase 2, regulatory subunit B', δ, TEG-271, Tex271
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppp2r5d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein phosphatase
  • phosphatase
  • protein phosphatase regulator
  • Protein phosphatase 2A regulatory B subunit (B56 family)
  • phosphatase activator
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • epithelial cancer
  • epithelial neoplasia
  • abdominal cancer
  • cancer
  • digestive system cancer
  • liver cancer
  • liver neoplasia
  • autosomal dominant mental retardation type 35
  • neurodevelopmental disorder
  • heart failure
regulated by
regulates
role in cell
  • proliferation
  • phosphorylation in
  • expression in
  • damage in
  • development
  • damage
  • checkpoint recovery in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • cytosol
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Ppp2r5d gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • signal transduction
  • negative regulation of peptidyl-threonine phosphorylation
  • protein dephosphorylation
  • nervous system development
  • positive regulation of protein dephosphorylation

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytosol
  • protein phosphatase type 2A complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • phosphoprotein phosphatase activity
  • protein binding
  • protein phosphatase activator activity
  • protein phosphatase regulator activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.