Acap1 Gene Summary [Rat]
Predicted to enable GTPase activator activity and zinc ion binding activity. Predicted to be located in endosome membrane. Orthologous to human ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acap1 |
| Official Name | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 [Source:RGD Symbol;Acc:1305360] |
| Ensembl ID | ENSRNOG00000015674 |
| Bio databases IDs | |
| Aliases | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 |
| Synonyms | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1, Centaurin b1 homolog, CENTB1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BAR domain of APPL family
- Ankyrin repeats (many copies)
- Putative GTP-ase activating proteins for the small GTPase, ARF
- Ankyrin repeats (3 copies)
- PH domain
- BAR domain
- protein binding
- Pleckstrin homology-like domain
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Bin/Amphiphysin/Rvs domain
- Putative GTPase activating protein for Arf
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- androgenic alopecia
- hypothyroidism
- thyroid disease
- insulin-dependent diabetes mellitus
- autoimmune thyroid disease
role in cell
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosol
- plasma membrane projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
Cellular Component
Where in the cell the gene product is active
- membrane
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- GTPase activator activity