Akt2 Gene Summary [Rat]
Enables ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; positive regulation of D-glucose import; and positive regulation of metabolic process. Acts upstream of or within cellular response to insulin stimulus and positive regulation of sodium ion transport. Located in insulin-responsive compartment and sarcoplasmic reticulum. Used to study high grade glioma and ischemia. Biomarker of colorectal cancer; hepatocellular carcinoma; hypertension; and obesity. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple) and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akt2 |
| Official Name | AKT serine/threonine kinase 2 [Source:RGD Symbol;Acc:2082] |
| Ensembl ID | ENSRNOG00000018677 |
| Bio databases IDs | |
| Aliases | AKT serine/threonine kinase 2 |
| Synonyms | 2410016A19Rik, AKT serine/threonine kinase 2, HIHGHH, PKB, PKBB, PKBBETA, Pkb β, PRKBB, Protein kinase Akt-2, RAC-BETA, RAC-β, thymoma viral proto-oncogene 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Akt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein kinase C terminal domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein kinase C binding
- ATP binding
- linker domain
- protein binding
- Pleckstrin homology-like domain
- variable loop
- Protein kinase domain
- proline rich domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- alcohol group acceptor phosphotransferase
- PH domain
- prolyl hydroxylase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Akt2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Angiopoietin Signaling
- Apelin Cardiac Fibroblast Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cancer Drug Resistance By Drug Efflux
- CXCR4 Signaling
- DNA damage-induced 14-3-3σ Signaling
- Docosahexaenoic Acid (DHA) Signaling
- EGF Signaling
- FGF Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- GP6 Signaling Pathway
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IGF-1 Signaling
- IL-22 Signaling
- JAK/Stat Signaling
- Mouse Embryonic Stem Cell Pluripotency
- Polyamine Regulation in Colon Cancer
- PXR/RXR Activation
- Sphingosine-1-phosphate Signaling
- Systemic Lupus Erythematosus Signaling
- Thyroid Cancer Signaling
- TR/RXR Activation
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- neoplasia
- epithelial neoplasia
- cancer
- invasive breast cancer
- perimenopausal breast cancer
- colitis
- metastatic breast cancer
- metastatic castration resistant prostate adenocarcinoma
role in cell
- expression in
- activation in
- phosphorylation in
- production in
- polymerization in
- quantity
- aggregation
- degradation in
- transcription in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- plasma membrane fraction
- intracellular membrane-bounded organelle
- perinuclear region
- cell cortex
- Nucleus
- Plasma Membrane
- endosomes
- sarcoplasmic reticulum
- vesicles
- cytosol
- basal cell surfaces
- membrane ruffles
- nucleoplasm
- secretory granules
- axon terminals
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Akt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- positive regulation of protein targeting to membrane
- insulin receptor signaling pathway
- fat cell differentiation
- glucose metabolic process
- positive regulation of glycogen biosynthetic process
- mammary gland epithelial cell differentiation
- cellular response to insulin stimulus
- regulation of translation
- peripheral nervous system myelin maintenance
- regulation of cell cycle
- intracellular signal transduction
- signal transduction
- positive regulation of fatty acid beta-oxidation
- positive regulation of glucose import
- glycogen biosynthetic process
- positive regulation of glucose metabolic process
- cellular response to high light intensity
- negative regulation of plasma membrane long-chain fatty acid transport
- regulation of cell migration
- peptidyl-serine phosphorylation
- protein localization in plasma membrane
- positive regulation of cell motility
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- intracellular membrane-bounded organelle
- cell cortex
- cytosol
- ruffle membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity