Dok4 Gene Summary [Rat]
Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within nervous system development and positive regulation of MAPK cascade. Predicted to be active in cytoplasm. Orthologous to human DOK4 (docking protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dok4 |
| Official Name | docking protein 4 [Source:RGD Symbol;Acc:1310084] |
| Ensembl ID | ENSRNOG00000015679 |
| Bio databases IDs | |
| Aliases | docking protein 4 |
| Synonyms | docking protein 4, IRS-5, LOC100040942 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dok4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PTB domain (IRS-1 type)
- PH domain
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
Pathways
Biological processes and signaling networks where the Dok4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- mitochondrial fraction
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dok4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- transmembrane receptor protein tyrosine kinase signaling pathway
- Ras protein signal transduction
- positive regulation of MAPK cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding