Reps2 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Predicted to be involved in endocytosis and endosomal transport. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human REPS2 (RALBP1 associated Eps domain containing 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Reps2 |
| Official Name | RALBP1 associated Eps domain containing 2 [Source:RGD Symbol;Acc:1561642] |
| Ensembl ID | ENSRNOG00000061508 |
| Bio databases IDs | |
| Aliases | RALBP1 associated Eps domain containing 2 |
| Synonyms | POB1, RALBP1 associated Eps domain containing 2, RALBP1 associated Eps domain containing protein 2, Reps2-ps1, RGD1561642 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Reps2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain pair
- calcium ion binding
- EFh
- protein binding
- Eps15 homology domain
- proline rich domain
- Cytoskeletal-regulatory complex EF hand
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- COVID-19
- renal cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- kidney carcinoma
role in cell
- apoptosis
- migration
- inhibition in
- receptor-mediated endocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Reps2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- epidermal growth factor receptor signaling pathway
- endosomal transport
- endocytosis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding