Arhgap35 Gene Summary [Rat]
Enables GTPase activating protein binding activity and GTPase activator activity. Involved in positive regulation of GTPase activity. Predicted to be located in actin cytoskeleton; ciliary basal body; and cytoplasm. Predicted to be active in cytosol. Orthologous to human ARHGAP35 (Rho GTPase activating protein 35). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap35 |
| Official Name | Rho GTPase activating protein 35 [Source:RGD Symbol;Acc:1308738] |
| Ensembl ID | ENSRNOG00000015852 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 35 |
| Synonyms | 6430596G11RIK, GRF-1, GRLF1, LOC686520, mKIAA1722, P190-A, p190ARhoGAP, p190RhoGAP, Rho GTPase activating protein 35 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgap35 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- phospholipid binding
- transcription regulator
- Contains two conserved F residues
- central domain
- GTPase activator
- protein binding
- RhoGAP
- GTPase-activator protein for Rho-like GTPases
- KEN box
- FF domain
- binding protein
- destruction box
- pseudoGTPase domain found in the family of p190RhoGAP
- p190-A and -B Rho GAPs FF domain
Pathways
Biological processes and signaling networks where the Arhgap35 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- hyperplasia
- Martsolf syndrome
- lung squamous cell carcinoma
- squamous cell lung cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- hypoplasia
- spina bifida
role in cell
- quantity
- migration
- assembly
- length
- expression in
- number
- formation
- development
- area
- permeability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- actin cytoskeleton
- basal bodies
- cytosol
- membrane ruffles
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgap35 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- wound healing, spreading of cells
- negative regulation of Rho protein signal transduction
- central nervous system neuron axonogenesis
- regulation of cell size
- regulation of actin polymerization or depolymerization
- axon guidance
- Rho protein signal transduction
- negative regulation of vascular permeability
- positive regulation of flagellum assembly
- axonal fasciculation
- mammary gland development
- forebrain development
- regulation of actin cytoskeleton organization
- neural tube closure
- regulation of axonogenesis
- regulation of small GTPase mediated signal transduction
- camera-type eye development
- positive regulation of neuron projection development
- establishment or maintenance of actin cytoskeleton polarity
- cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cilium basal body
- actin cytoskeleton
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- DNA binding
- GTPase activity
- GTPase activator activity
- phospholipid binding