Ctsa Gene Summary [Mouse]

This gene encodes a glycoprotein with deamidase, esterase and carboxypeptidase activities. The encoded protein associates with and provides a protective function to the lysosomal enzymes beta-galactosidase and neuraminidase. Deficiency of the related gene in humans results in galactosialidosis. The proprotein is processed into two shorter chains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

Details

Type
Protein Coding
Official Symbol
Ctsa
Official Name
cathepsin A [Source:MGI Symbol;Acc:MGI:97748]
Ensembl ID
ENSMUSG00000017760
Bio databases IDs NCBI: 19025 Ensembl: ENSMUSG00000017760
Aliases cathepsin A
Synonyms Cathepsin A, GLB2, GSL, LYSOSOMAL SERINE CARBOXYPEPTIDASE, NGBE, PPCA, PPGB
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctsa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • carboxypeptidase
  • carboxypeptidase C
  • PLN02209
  • serine-type carboxypeptidase
  • peptidase
  • Serine carboxypeptidase
  • protein binding
  • enzyme activator activity

Pathways

Biological processes and signaling networks where the Ctsa gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • galactosialidosis
  • hereditary disorder
  • anaplastic thyroid carcinoma
  • anaplastic thyroid cancer
  • epithelial thyroid cancer
  • peripheral arterial disease
  • systemic lupus erythematosus
  • idiopathic hydrops fetalis
  • galactosialidosis type II
  • juvenile/adult type galactosialidosis
regulated by
regulates
role in cell
  • apoptosis
  • accumulation in
  • number
  • diameter
  • quantity
  • abnormal morphology

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • soluble fraction
  • multivesicular domain
  • intracellular membrane-bounded organelle
  • azurophil granule lumen
  • Extracellular Space
  • lysosome
  • Endoplasmic Reticulum
  • lysosomal compartment
  • phagosomes
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctsa gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of protein stability
  • proteolysis
  • intracellular protein transport

Cellular Component

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • intracellular membrane-bounded organelle
  • membrane
  • endoplasmic reticulum
  • lysosomal lumen
  • extracellular region
  • azurophil granule lumen
  • lysosome

Molecular Function

What the gene product does at the molecular level
  • carboxypeptidase activity
  • serine-type carboxypeptidase activity
  • enzyme activator activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.