Npsr1 Gene Summary [Rat]
Predicted to enable neuropeptide receptor activity. Involved in several processes, including negative regulation of defecation; positive regulation of ERK1 and ERK2 cascade; and righting reflex. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Biomarker of morphine dependence. Human ortholog(s) of this gene implicated in asthma; inflammatory bowel disease; newborn respiratory distress syndrome; and rheumatoid arthritis. Orthologous to human NPSR1 (neuropeptide S receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npsr1 |
| Official Name | neuropeptide S receptor 1 [Source:RGD Symbol;Acc:1564154] |
| Ensembl ID | ENSRNOG00000015863 |
| Bio databases IDs | |
| Aliases | neuropeptide S receptor 1 |
| Synonyms | 9330128H10Rik, ASRT2, GPR154, GPRA, MVTR, neuropeptide S receptor 1, NPSR, NPS receptor, PGR14, RGD1564154, VRR1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Npsr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- neuropeptide receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Npsr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- righting reflex
- negative regulation of defecation
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of release of sequestered calcium ion into cytosol
- eating behavior
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neuropeptide receptor activity
- vasopressin receptor activity