Pif1 Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; helicase activity; and magnesium ion binding activity. Predicted to be involved in negative regulation of telomere maintenance via telomerase and protein-DNA-RNA complex disassembly. Predicted to be located in chromosome, telomeric region; mitochondrial nucleoid; and nucleus. Orthologous to human PIF1 (PIF1 5'-to-3' DNA helicase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pif1 |
| Official Name | PIF1 5'-to-3' DNA helicase [Source:RGD Symbol;Acc:1586053] |
| Ensembl ID | ENSRNOG00000015878 |
| Bio databases IDs | |
| Aliases | PIF1 5'-to-3' DNA helicase |
| Synonyms | 4631410M14, C15orf20, FLJ22692, LOC690796, PIF, PIF1 5'-to-3' DNA helicase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pif1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA dependent ATP dependent DNA helicase
- PIF1-like helicase
- helicase
- ATP binding
- enzyme
- DNA dependent ATPase
- magnesium ion binding
- RNA dependent ATPase
- telomeric DNA binding
- DNA helicase
- AAA domain
- N-terminal helicase domain of the DEAD-box helicase superfamily
- UvrD-like helicase C-terminal domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- mitochondrial nucleoids
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pif1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA replication
- DNA duplex unwinding
- DNA recombination
- telomere maintenance via telomerase
- negative regulation of telomere maintenance via telomerase
- negative regulation of telomerase activity
- regulation of telomere maintenance
- mitochondrial genome maintenance
Cellular Component
Where in the cell the gene product is active
- replication fork
- chromosome, telomeric region
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATPase activity
- ATP binding
- G-quadruplex DNA binding
- telomeric DNA binding
- 5'-3' DNA/RNA helicase activity
- telomerase inhibitor activity
- single-stranded DNA-dependent ATP-dependent DNA helicase activity
- 5'-3' DNA helicase activity