Ano5 Gene Summary [Rat]
Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport and plasma membrane repair. Predicted to be located in vesicle. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Miyoshi muscular dystrophy 3; autosomal recessive limb-girdle muscular dystrophy type 2L; gnathodiaphyseal dysplasia; and isolated elevated serum creatine phosphokinase levels. Orthologous to human ANO5 (anoctamin 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ano5 |
| Official Name | anoctamin 5 [Source:RGD Symbol;Acc:1564265] |
| Ensembl ID | ENSRNOG00000015972 |
| Bio databases IDs | |
| Aliases | anoctamin 5 |
| Synonyms | 9330162L24, anoctamin 5, GDD1, LGMD2L, LGMDR12, RGD1564265, TMEM16E |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ano5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcium-activated chloride channel
- dimerization domain of Ca+-activated chloride-channel, anoctamin
- chloride channel
- intracellular calcium activated chloride channel
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- limb-girdle muscular dystrophy type 2L
- gnathodiaphyseal dysplasia
- Miyoshi muscular dystrophy type 3
- schizophrenia
- limb-girdle muscular dystrophy type 2
- muscular dystrophy
- plasma cell myeloma
- pruritus
- ANO5-related disorder
role in cell
- motility
- repair
- repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- vesicles
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ano5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- plasma membrane repair
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- intracellular calcium activated chloride channel activity
- protein dimerization activity
- chloride channel activity