Anxa6 Gene Summary [Rat]
Enables calcium-dependent phospholipid binding activity. Predicted to be involved in several processes, including apoptotic signaling pathway; mitochondrial calcium ion homeostasis; and negative regulation of sequestering of calcium ion. Predicted to act upstream of or within regulation of muscle contraction. Located in apical plasma membrane; intercalated disc; and sarcolemma. Part of protein-containing complex. Orthologous to human ANXA6 (annexin A6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Anxa6 |
| Official Name | annexin A6 [Source:RGD Symbol;Acc:621172] |
| Ensembl ID | ENSRNOG00000010668 |
| Bio databases IDs | |
| Aliases | annexin A6 |
| Synonyms | annexin A6, Annexin VI, ANX6, AnxVI, Cabm, CALPHOBINDIN2, Camb, CBP68, CPB-II, p68, p70 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Anxa6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- calcium-dependent protein binding
- cholesterol binding
- lipid binding
- binding protein
- calcium-dependent phospholipid binding
- ligand-gated ion channel
- Annexin
- protein binding
- identical protein binding
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- metastasis
- organismal death
- major depression
- idiopathic scoliosis
- diffuse systemic sclerosis
- Waldenström macroglobulinemia
role in cell
- degradation in
- proliferation
- activation in
- mitochondrial respiration in
- phosphorylation in
- expression in
- generation in
- transmembrane potential
- differentiation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- early endosomal fractions
- myelin enriched fraction
- detergent resistant lipid raft fraction
- caveolae-derived endocytic vesicles
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- lysosome
- Mitochondria
- intercellular junctions
- lipid droplets
- cytosol
- apical cytoplasm
- basal cytoplasm
- apical membrane
- pre-lysosomal compartments
- lysosome membrane
- endosomal membrane
- zymogen granules
- sarcolemma
- smooth microsomes
- membrane rafts
- exosomes
- late endosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Anxa6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
- calcium ion transport
- mitochondrial calcium ion homeostasis
- regulation of muscle contraction
- apoptotic signaling pathway
- negative regulation of sequestering of calcium ion
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- focal adhesion
- melanosome
- cytoplasm
- vesicle membrane
- sarcolemma
- membrane
- mitochondrion
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- phosphatidylserine binding
- protein binding
- cholesterol binding
- ligand-gated ion channel activity
- calcium ion binding
- calcium-dependent protein binding
- lipid binding
- calcium-dependent phospholipid binding