Cyp1a2

Enables nitrite reductase (NO-forming) activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including cellular response to copper ion; nitroglycerin metabolic process; and response to tetrachloromethane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Biomarker of congestive heart failure and depressive disorder. Human ortholog(s) of this gene implicated in breast cancer; chronic obstructive pulmonary disease; endometrial cancer; and porphyria cutanea tarda. Orthologous to human CYP1A2 (cytochrome P450 family 1 subfamily A member 2). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp1a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Cyp1a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.