Ccl17 Gene Summary [Rat]
Enables CCR4 chemokine receptor binding activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide. Predicted to act upstream of or within negative regulation of myoblast differentiation. Predicted to be located in extracellular space. Biomarker of anti-basement membrane glomerulonephritis; asthma; pneumonia; and pulmonary fibrosis. Orthologous to human CCL17 (C-C motif chemokine ligand 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccl17 |
| Official Name | C-C motif chemokine ligand 17 [Source:RGD Symbol;Acc:619924] |
| Ensembl ID | ENSRNOG00000016278 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 17 |
| Synonyms | A-152E5.3, ABCD-2, C-C motif chemokine ligand 17, SCYA17, Scya17l, TARC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccl17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the Ccl17 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- preeclampsia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- airway hyperresponsiveness
- breast carcinoma
- atopic dermatitis
- T-cell large granular lymphocytic leukemia
- papillary thyroid carcinoma
- papillary thyroid cancer
role in cell
- expression in
- differentiation
- migration
- proliferation
- inhibition in
- chemotaxis
- activation
- formation
- emigration
- mobility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
- apical compartment
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccl17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- inflammatory response
- chemokine-mediated signaling pathway
- cell-cell signaling
- positive regulation of GTPase activity
- positive regulation of cell migration
- cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- CCR chemokine receptor binding
- protein binding
- chemokine activity
- receptor binding