Entpd4 Gene Summary [Rat]
Predicted to enable pyrophosphatase activity. Predicted to be involved in nucleobase-containing small molecule metabolic process. Predicted to be located in Golgi membrane and autophagosome membrane. Predicted to be active in Golgi apparatus and membrane. Orthologous to human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Entpd4 |
| Official Name | ectonucleoside triphosphate diphosphohydrolase 4 [Source:RGD Symbol;Acc:1309511] |
| Ensembl ID | ENSRNOG00000016321 |
| Bio databases IDs | |
| Aliases | ectonucleoside triphosphate diphosphohydrolase 4 |
| Synonyms | A430102M06RIK, ectonucleoside triphosphate diphosphohydrolase 4, LALP70, LAP70, LYSAL1, NTPDase-4, UDPase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Entpd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-triphosphatase
- guanosine-diphosphatase
- nucleoside-diphosphatase
- uridine diphosphatase
- enzyme
- protein binding
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- glioblastoma cancer
- atopic dermatitis
regulates
- uridine diphosphate
- GDP
- CTP
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
- lysosome membrane
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Entpd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- CTP metabolic process
- UDP catabolic process
- GDP catabolic process
- nucleobase-containing small molecule catabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- cytoplasmic vesicle
- Golgi apparatus
- Golgi membrane
- lysosomal membrane
- autophagic vacuole membrane
Molecular Function
What the gene product does at the molecular level
- CTPase activity
- uridine-diphosphatase activity
- guanosine-diphosphatase activity
- GTPase activity
- nucleoside-diphosphatase activity
- nucleoside-triphosphatase activity