Colec12 Gene Summary [Rat]
Predicted to enable low-density lipoprotein particle binding activity; pattern recognition receptor activity; and scavenger receptor activity. Predicted to be involved in several processes, including cellular response to exogenous dsRNA; phagocytosis, recognition; and toll-like receptor 3 signaling pathway. Predicted to act upstream of with a positive effect on plasma membrane raft organization. Predicted to act upstream of or within immune response. Predicted to be located in membrane. Predicted to be part of collagen trimer. Orthologous to human COLEC12 (collectin subfamily member 12). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Colec12 |
| Official Name | collectin sub-family member 12 [Source:RGD Symbol;Acc:735039] |
| Ensembl ID | ENSRNOG00000016366 |
| Bio databases IDs | |
| Aliases | collectin sub-family member 12 |
| Synonyms | CL-P1, collectin sub-family member 12, NSR2, SCARA4, SRCL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Colec12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- scavenger receptor
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- carbohydrate recognition domain
- Lectin C-type domain
- Collagen triple helix repeat (20 copies)
- low-density lipoprotein binding
- protein binding
- carbohydrate binding
- transmembrane receptor
- Laminin Domain I
Pathways
Biological processes and signaling networks where the Colec12 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- Duchenne muscular dystrophy
- schizophrenia
- autosomal dominant Emery-Dreifuss muscular dystrophy
- Hutchinson-Gilford progeria syndrome
- metastatic colorectal cancer
- drusen
- juvenile dermatomyositis
- self-abusive behavior
- dementia
role in cell
- expression in
- binding
- phagocytosis by
- phagocytosis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- endocytic vesicle membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Colec12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phagocytosis, recognition
- cellular response to exogenous dsRNA
- innate immune response
- toll-like receptor 3 signaling pathway
- defense response
- defense response to bacterium
- carbohydrate mediated signaling
Cellular Component
Where in the cell the gene product is active
- extracellular space
- collagen
- membrane
- endocytic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- scavenger receptor activity
- low-density lipoprotein particle binding
- galactose binding