Nox3 Gene Summary [Rat]
Predicted to enable heme binding activity and superoxide-generating NAD(P)H oxidase activity. Predicted to be involved in defense response and superoxide anion generation. Predicted to act upstream of or within detection of gravity; otolith development; and temperature homeostasis. Predicted to be located in cytoplasm. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Orthologous to human NOX3 (NADPH oxidase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nox3 |
| Official Name | NADPH oxidase 3 [Source:RGD Symbol;Acc:1303190] |
| Ensembl ID | ENSRNOG00000016490 |
| Bio databases IDs | |
| Aliases | NADPH oxidase 3 |
| Synonyms | GP91-3, het, MOX-2, NADPH oxidase 3, nmf250 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nox3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FNR_like
- oxidoreductase
- Cytochrome_b_N
- enzyme
- protein binding
- heme binding
- Oxidoreductase NAD-binding domain
- superoxide-generating NADPH oxidase
Pathways
Biological processes and signaling networks where the Nox3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- insulin resistance
- Wallerian degeneration
role in cell
- cell death
- production in
- activation in
- expression in
- phosphorylation in
- generation in
- lipolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nox3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of gravity
- otolith development
- temperature homeostasis
- defense response
- superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- NADPH oxidase complex
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- superoxide-generating NADPH oxidase activity
- heme binding