Khk Gene Summary [Rat]
Enables ketohexokinase activity. Involved in several processes, including response to hexose; response to insulin; and response to sucrose. Predicted to be located in nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in essential fructosuria. Orthologous to human KHK (ketohexokinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Khk |
| Official Name | ketohexokinase [Source:RGD Symbol;Acc:2966] |
| Ensembl ID | ENSRNOG00000008047 |
| Bio databases IDs | |
| Aliases | ketohexokinase |
| Synonyms | Fructokinase, FRUCTU, KETHPRO, ketohexokinase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Khk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- ribokinase_pfkB_like
- monosaccharide binding
- ribokinase
- ketohexokinase
- ATP binding
- protein homodimerization
- protein binding
- pfkB family carbohydrate kinase
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- essential fructosuria
role in cell
- expression in
- cell viability
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Khk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to glucose stimulus
- response to zinc ion
- response to insulin stimulus
- response to fructose stimulus
- fructose metabolic process
- regulation of glycogen metabolic process
- carbohydrate phosphorylation
- response to sucrose stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- ketohexokinase activity