Chka Gene Summary [Mouse]
Enables choline kinase activity; cholinesterase activity; and identical protein binding activity. Acts upstream of or within phosphatidylcholine biosynthetic process. Predicted to be located in lipid droplet. Predicted to be active in cytosol. Is expressed in several structures, including future brain; gut; liver; metanephros; and neural retina. Orthologous to human CHKA (choline kinase alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Chka |
| Official Name | choline kinase alpha [Source:MGI Symbol;Acc:MGI:107760] |
| Ensembl ID | ENSMUSG00000024843 |
| Bio databases IDs | |
| Aliases | choline kinase alpha |
| Synonyms | Chetk-alpha, Chetk-α, CHK, ChoK, CHOLINE KINASE, choline kinase alpha, choline kinase α, CK, CKalpha, CK/EK-alpha, CK/EK-α, CKI, CK-R, EK, EtnK-alpha, EtnK-α, NEDMIMS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chka often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- cholinesterase
- binding protein
- Protein Kinases, catalytic domain
- ATP binding
- Phosphotransferase enzyme family
- protein homodimerization
- ethanolamine kinase
- protein binding
- protein-tyrosine kinase
- identical protein binding
- choline kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with microcephaly, movement abnormalities, and seizures
- head and neck neoplasia
- streptozotocin induced type1 diabetes
- pituitary gland adenoma
- adenoma formation
- head and neck neuroendocrine neoplasia
role in cell
- expression in
- proliferation
- apoptosis
- activation in
- phosphorylation in
- growth
- binding in
- disassembly
- survival
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lipid droplets
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chka gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- phosphatidylethanolamine biosynthetic process
- CDP-choline pathway
- lipid metabolic process
- phosphatidylcholine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein homodimerization activity
- ethanolamine kinase activity
- cholinesterase activity
- choline kinase activity