Cyp27a1 Gene Summary [Rat]
Enables Hsp70 protein binding activity; cholesterol 26-hydroxylase activity; and vitamin D3 25-hydroxylase activity. Involved in cholesterol metabolic process. Located in mitochondrial inner membrane. Biomarker of extrahepatic cholestasis. Human ortholog(s) of this gene implicated in cerebrotendinous xanthomatosis. Orthologous to human CYP27A1 (cytochrome P450 family 27 subfamily A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp27a1 |
| Official Name | cytochrome P450, family 27, subfamily a, polypeptide 1 [Source:RGD Symbol;Acc:727915] |
| Ensembl ID | ENSRNOG00000017188 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 27, subfamily a, polypeptide 1 |
| Synonyms | 1300013A03Rik, C27/25, C27 HYDROXYLASE, CP27, CTX, CYP27, Cyp27 alpha, Cyp27 α, cytochrome P450 family 27 subfamily A member 1, cytochrome P450, family 27, subfamily a, polypeptide 1, P450C27, Sterol 27-Hydroxylase, α conotoxin mi |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp27a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cholestanetetraol 26-dehydrogenase
- cholestanetriol 26-monooxygenase
- Hsp70 protein binding
- cholesterol 7alpha-monooxygenase
- heme binding domain
- enzyme
- steroid hydroxylase
- heme binding
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- vitamin D3 25-hydroxylase
- adrenodoxin binding domain
- cholesterol monooxygenase (side-chain-cleaving)
- monophenol:oxygen oxidoreductase
Pathways
Biological processes and signaling networks where the Cyp27a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cholestasis
- liver disease
- liver cancer
- epithelial cancer
- cerebrotendinous xanthomatosis
- hepatitis B virus-related hepatocellular carcinoma
- androgenic alopecia
- lung adenocarcinoma
- lung adenocarcinoma formation
- preeclampsia
role in cell
- production in
- expression in
- quantity
- differentiation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cyp27a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cholesterol catabolic process
- cholesterol metabolic process
- bile acid biosynthetic process
- sterol metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- iron ion binding
- steroid hydroxylase activity
- cholesterol 26-hydroxylase activity
- vitamin D3 25-hydroxylase activity
- cholestanetetraol 26-dehydrogenase activity
- heme binding