Cdk11b Gene Summary [Rat]
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including protein phosphorylation; regulation of cell growth; and regulation of mRNA processing. Predicted to act upstream of or within blastocyst development; negative regulation of apoptotic signaling pathway; and regulation of mitotic nuclear division. Predicted to be located in nuclear membrane and perinuclear region of cytoplasm. Predicted to be active in nucleus. Orthologous to several human genes including CDK11B (cyclin dependent kinase 11B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdk11b |
| Official Name | cyclin-dependent kinase 11B [Source:RGD Symbol;Acc:628604] |
| Ensembl ID | ENSRNOG00000017213 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase 11B |
| Synonyms | Cdc11b, CDC2L1, Cdc2l2, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, cyclin-dependent kinase 11B, LOC100133692, p58, p58CDC2L1, p58CLK-1, Pitslre, PITSLREA, PK58 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdk11b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- PKD domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Cdk11b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- latent tuberculosis
role in cell
- expression in
- apoptosis
- cell viability
- proliferation
- quantity
- growth
- survival
- ciliogenesis in
- signaling in
- early G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- Golgi-intermediate compartment membrane fractions
- Cytoplasm
- vesicles
- cis face of the Golgi apparatus
- Golgi membrane
- nucleoplasm
- interchromatin granule clusters
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdk11b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mRNA processing
- regulation of cell growth
- apoptotic process
- regulation of transcription, DNA-dependent
- protein phosphorylation
- regulation of mitotic cell cycle
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- RNA binding
- protein binding
- protein kinase activity
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity