CDK11B Gene Summary [Human]
This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | CDK11B |
| Official Name | cyclin dependent kinase 11B [Source:HGNC Symbol;Acc:HGNC:1729] |
| Ensembl ID | ENSG00000248333 |
| Bio databases IDs | |
| Aliases | cyclin dependent kinase 11B |
| Synonyms | Cdc11b, CDC2L1, Cdc2l2, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, cyclin-dependent kinase 11B, LOC100133692, p58, p58CDC2L1, p58CLK-1, Pitslre, PITSLREA, PK58 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDK11B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- PKD domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the CDK11B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- latent tuberculosis
role in cell
- expression in
- apoptosis
- cell viability
- proliferation
- quantity
- growth
- survival
- ciliogenesis in
- signaling in
- early G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- membrane fraction
- Golgi-intermediate compartment membrane fractions
- Cytoplasm
- vesicles
- cis face of the Golgi apparatus
- Golgi membrane
- nucleoplasm
- interchromatin granule clusters
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDK11B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mRNA processing
- regulation of cell growth
- apoptotic process
- regulation of transcription, DNA-dependent
- protein phosphorylation
- regulation of mitotic cell cycle
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- RNA binding
- protein binding
- protein kinase activity
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity