Mfge8 Gene Summary [Rat]
Predicted to enable integrin binding activity and phosphatidylserine binding activity. Involved in positive regulation of cell population proliferation and response to estrogen. Predicted to be located in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in temporal arteritis. Orthologous to human MFGE8 (milk fat globule EGF and factor V/VIII domain containing). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mfge8 |
| Official Name | milk fat globule-EGF factor 8 protein [Source:RGD Symbol;Acc:3083] |
| Ensembl ID | ENSRNOG00000017510 |
| Bio databases IDs | |
| Aliases | milk fat globule-EGF factor 8 protein |
| Synonyms | AGS, BA46, EDIL1, HMFG, hP47, HsT19888, lactadherin, MFG, MFGM, MFGME8, MFGMP-E8, milk fat globule EGF and factor V/VIII domain containing, Milk fat globule-EGF factor 8, MP47, OAcGD3S, P47, SED1, SPAG10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mfge8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- phosphatidylserine binding pocket
- binding protein
- Coagulation factor 5/8 C-terminal domain, discoidin domain
- integrin binding
- RGD motif
- F5/8 type C domain
- Proline threonine rich domain
- EGF-like domain
- EGF_CA
- FA58C
Pathways
Biological processes and signaling networks where the Mfge8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- glomerulonephritis
- atherosclerosis
- neoplasia
- splenomegaly
- hyperplasia
- prostate cancer
- cardiac hypertrophy
- bladder carcinoma
- epithelial cancer
role in cell
- apoptosis
- proliferation
- phosphorylation in
- migration
- activity
- expression in
- quantity
- growth
- osteoclastogenesis
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- cell surface
- cellular membrane
- Golgi Apparatus
- apical cell surfaces
- endoplasmic reticulum lumen
- plasma membrane extracellular face
- exosomes
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mfge8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- apoptotic cell clearance
- cell adhesion
- single fertilization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- acrosomal membrane
- membrane
- external side of plasma membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- integrin binding
- extracellular matrix structural constituent