ALDH3B1 Gene Summary [Human]
This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | ALDH3B1 |
| Official Name | aldehyde dehydrogenase 3 family member B1 [Source:HGNC Symbol;Acc:HGNC:410] |
| Ensembl ID | ENSG00000006534 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 3 family member B1, aldehyde dehydrogenase 7, aldehyde dehydrogenase 3B1 |
| Synonyms | 1700001N19RIK, aldehyde dehydrogenase 3 family member B1, aldehyde dehydrogenase 3 family, member B1, ALDH4, ALDH7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ALDH3B1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldehyde dehydrogenase family
- Acyl-CoA reductase (LuxC)
- betaine-aldehyde dehydrogenase
- aldehyde dehydrogenase [NAD(P)]
- aldehyde dehydrogenase (NAD)
- 1-pyrroline dehydrogenase
- aldehyde dehydrogenase
- enzyme
- protein binding
- delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative
- delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain)
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
Pathways
Biological processes and signaling networks where the ALDH3B1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- lipid
- trans-2-nonenal
- medium-chain aldehyde
- aldehyde
- hexanal
- octanal
- nonanal
- long-chain aldehyde
- alcohol
- trans-2-octenal
role in cell
- cell death
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Plasma Membrane
- secretory granule membrane
- specific granule membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ALDH3B1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- aldehyde catabolic process
- response to oxidative stress
- cellular aldehyde metabolic process
- lipid metabolic process
- ethanol catabolic process
- cellular response to oxidative stress
- alcohol metabolic process
- sphingolipid catabolic process
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular vesicular exosome
- cytoplasm
- cytosol
- vesicle
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- aldehyde dehydrogenase (NAD) activity
- 3-chloroallyl aldehyde dehydrogenase activity
- protein binding
- aldehyde dehydrogenase [NAD(P)+] activity
- benzaldehyde dehydrogenase (NADP+) activity
- benzaldehyde dehydrogenase (NAD+) activity