H6pd Gene Summary [Rat]
Enables NADP binding activity; carbohydrate binding activity; and glucose-6-phosphate dehydrogenase activity. Involved in NADP metabolic process; response to alcohol; and response to nutrient levels. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in cortisone reductase deficiency; cortisone reductase deficiency 1; and multiple sclerosis. Orthologous to human H6PD (hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | H6pd |
| Official Name | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [Source:RGD Symbol;Acc:1306562] |
| Ensembl ID | ENSRNOG00000017523 |
| Bio databases IDs | |
| Aliases | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) |
| Synonyms | BC009563, CORTRD1, G6PD1, G6PDH, GDH, Gpd-1, H6PDH, hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase), hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat H6pd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SugarP_isomerase
- glucose 1-dehydrogenase
- Glucose-6-phosphate dehydrogenase, C-terminal domain
- Glucose-6-phosphate dehydrogenase, NAD binding domain
- NADP binding
- glucose-6-phosphate 1-dehydrogenase
- 6-phosphogluconolactonase
- Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
- enzyme
- carbohydrate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- deficiency of (r)-20-hydroxysteroid dehydrogenase
- weight gain
- centronuclear myopathy
- hypoglycemia
role in cell
- expression in
- activation in
- depletion in
- abnormal morphology
- cell viability
- vacuolation in
- vacuolation
- conversion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- microsome
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat H6pd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pentose-phosphate shunt, oxidative branch
- regulation of cortisol biosynthetic process
- response to alcohol
- glucose metabolic process
- response to nutrient levels
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- NADP binding
- 6-phosphogluconolactonase activity
- carbohydrate binding
- glucose 1-dehydrogenase [NAD(P)] activity
- glucose 1-dehydrogenase (NADP+) activity
- glucose 1-dehydrogenase (NAD+) activity
- glucose-6-phosphate dehydrogenase activity