Wdfy2 Gene Summary [Rat]
Predicted to enable zinc ion binding activity. Predicted to be involved in positive regulation of fat cell differentiation and positive regulation of protein phosphorylation. Predicted to be located in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Predicted to be active in early endosome. Orthologous to human WDFY2 (WD repeat and FYVE domain containing 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdfy2 |
| Official Name | WD repeat and FYVE domain containing 2 [Source:RGD Symbol;Acc:1307337] |
| Ensembl ID | ENSRNOG00000010042 |
| Bio databases IDs | |
| Aliases | WD repeat and FYVE domain containing 2 |
| Synonyms | 5830485M08, B130024L21RIK, PROF, WDF2, WD repeat and FYVE domain containing 2, ZFYVE22 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wdfy2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- WD40 repeats
- Protein present in Fab1, YOTB, Vac1, and EEA1
- WD domain, G-beta repeat
- PHD finger superfamily
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- insulin resistance
role in cell
- expression in
- phosphorylation in
- molecular cleavage in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- endosomes
- vesicles
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wdfy2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein phosphorylation
- positive regulation of fat cell differentiation
Cellular Component
Where in the cell the gene product is active
- early endosome
- intracellular membrane-bounded organelle
- vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding