Fis1 Gene Summary [Rat]
Predicted to enable identical protein binding activity; lipid binding activity; and molecular adaptor activity. Involved in several processes, including cellular response to peptide; mitochondrial fragmentation involved in apoptotic process; and positive regulation of mitochondrial fission. Located in mitochondrial outer membrane and peroxisomal membrane. Biomarker of dental fluorosis; kidney failure (multiple); myocardial infarction; rhinitis; and steatotic liver disease. Orthologous to human FIS1 (fission, mitochondrial 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fis1 |
| Official Name | fission, mitochondrial 1 [Source:RGD Symbol;Acc:1306668] |
| Ensembl ID | ENSRNOG00000001420 |
| Bio databases IDs | |
| Aliases | fission, mitochondrial 1 |
| Synonyms | 2010003O14Rik, CGI-135, fission, mitochondrial 1, Riken cDNA 2010003o14, TTC11 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fis1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- alpha helix
- transmembrane domain
- protein binding
- Mitochondrial Fission Protein Fis1, cytosolic domain
- identical protein binding
- tetratricopeptide repeat
- sorting signal domain
- Fis1 N-terminal tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the Fis1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- muscular atrophy
- breast cancer
role in cell
- expression in
- proliferation
- apoptosis
- quantity
- mitochondrial fission
- swelling
- granularity
- response by
- fragmentation
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- mitochondrial outer membrane
- peroxisome membrane
- neurites
- peroxisomes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fis1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fatty acid transport
- peroxisome fission
- positive regulation of protein targeting to membrane
- mitochondrial fusion
- mitochondrial fragmentation involved in apoptotic process
- positive regulation of mitochondrial fission
- mitochondrion degradation
- mitochondrion organization
- mitochondrial fission
- protein targeting to mitochondrion
- release of cytochrome c from mitochondria
- regulation of mitochondrion organization
- positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- mitochondrion
- membrane
- cytosol
- macromolecular complex
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- lipid binding
- binding, bridging