Cd59 Gene Summary [Rat]
Enables complement binding activity. Involved in several processes, including negative regulation of activation of membrane attack complex; negative regulation of complement-dependent cytotoxicity; and positive regulation of T cell proliferation. Located in compact myelin; extracellular space; and sarcolemma. Used to study anterior uveitis; colorectal carcinoma; glomerulonephritis; nephrosis; and neuromyelitis optica. Biomarker of acute necrotizing pancreatitis; diabetic retinopathy; and myocardial infarction. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd59 |
| Official Name | CD59 molecule [Source:RGD Symbol;Acc:2311] |
| Ensembl ID | ENSRNOG00000042821 |
| Bio databases IDs | |
| Aliases | CD59 molecule |
| Synonyms | 16.3A5, 1F5, Cd59a, Cd59b, CD59b molecule, CD59 molecule (CD59 blood group), EJ16, EJ30, EL32, G344, HRF-20, MACIF, MAC-IP, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd59 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helical domain
- GPI anchor
- protein binding
- TFP
Pathways
Biological processes and signaling networks where the Cd59 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- atherosclerosis
- organismal death
- adjuvant arthritis
- CD59 deficiency
- CD59-mediated hemolytic anemia with immune-mediated polyneuropathy
- reperfusion injury
- pancreatic adenocarcinoma
- pancreatic epithelial cancer
role in cell
- cell death
- apoptosis
- proliferation
- cell cycle progression
- cytotoxicity
- activation
- adhesion
- morphology
- toxicity
- cytolysis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- Extracellular Space
- microvesicles
- cellular membrane
- vesicles
- tertiary granule membrane
- specific granule membrane
- apical cell surfaces
- basolateral cell surfaces
- endoplasmic reticulum membrane
- plasma membrane extracellular face
- Golgi membrane
- myelin sheath
- sarcolemma
- transport vesicles
- GLUT4 vesicles
- extracellular matrix
- membrane rafts
- detergent insoluble microdomains
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd59 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of activation of membrane attack complex
- regulation of complement activation
- cell surface receptor signaling pathway
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- Golgi membrane
- plasma membrane
- cell surface
- endoplasmic reticulum membrane
- extracellular space
- extracellular vesicular exosome
- focal adhesion
- ER to Golgi transport vesicle membrane
- membrane
- vesicle
- transport vesicle
- tertiary granule membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- complement binding