Mdk Gene Summary [Rat]
Predicted to enable glycosaminoglycan binding activity and growth factor activity. Involved in several processes, including adrenal gland development; response to glucocorticoid; and response to wounding. Located in cell projection. Used to study brain infarction and coronary stenosis. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mdk |
| Official Name | midkine [Source:RGD Symbol;Acc:69073] |
| Ensembl ID | ENSRNOG00000017560 |
| Bio databases IDs | |
| Aliases | midkine |
| Synonyms | ARAP, Mek, midkine, MK, NEGF2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mdk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
- heparin binding
- growth factor
- glycosaminoglycan binding
- PTN/MK heparin-binding protein family, N-terminal domain
Pathways
Biological processes and signaling networks where the Mdk gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- cancer
- epithelial cancer
- gastric cancer
- lung adenocarcinoma
- neoplasia
- gastric adenocarcinoma
- rheumatoid arthritis
- lung adenocarcinoma formation
- experimental autoimmune encephalomyelitis
role in cell
- expression in
- quantity
- cell death
- production in
- phosphorylation in
- proliferation
- formation in
- apoptosis
- formation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Plasma Membrane
- cellular protrusions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mdk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- regulation of chondrocyte differentiation
- T cell activation involved in immune response
- positive regulation of oligodendrocyte differentiation
- regulation of behavior
- cerebellar granular layer development
- positive regulation of transcription, DNA-dependent
- positive regulation of neuron projection development
- defecation
- intracellular signal transduction
- positive regulation of neutrophil chemotaxis
- positive regulation of inflammatory response
- positive regulation of leukocyte chemotaxis
- cerebral cortex development
- positive regulation of substrate adhesion-dependent cell spreading
- dentate gyrus development
- short-term memory
- positive regulation of T cell differentiation
- negative regulation of cardiac muscle cell apoptotic process
- positive regulation of cell migration
- positive regulation of cartilage development
- response to wounding
- nervous system development
- positive regulation of cell adhesion
- negative regulation of neuron apoptotic process
- positive regulation of epithelial to mesenchymal transition
- positive regulation of keratinocyte proliferation
- negative regulation of regulatory T cell differentiation
- positive regulation of cell division
- positive regulation of smooth muscle cell chemotaxis
- positive regulation of macrophage chemotaxis
- positive regulation of neural precursor cell proliferation
- response to auditory stimulus
- adrenal gland development
- positive regulation of neuron migration
- positive regulation of neutrophil extravasation
- signal transduction
- negative regulation of cell adhesion
- tissue regeneration
- leukocyte chemotaxis involved in inflammatory response
- behavioral fear response
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of interleukin-12 production
- regulation of bone remodeling
- oogenesis
- cell differentiation
- negative regulation of ossification
- positive regulation of hepatocyte proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- chondroitin sulfate binding
- growth factor activity
- protein binding
- heparin binding