Fbp2 Gene Summary [Rat]
Enables fructose 1,6-bisphosphate 1-phosphatase activity. Involved in gluconeogenesis. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Orthologous to human FBP2 (fructose-bisphosphatase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbp2 |
| Official Name | fructose-bisphosphatase 2 [Source:RGD Symbol;Acc:620930] |
| Ensembl ID | ENSRNOG00000017637 |
| Bio databases IDs | |
| Aliases | fructose-bisphosphatase 2 |
| Synonyms | CORLK, Fbp-1, FBPase, Fructose 1,6 bisphosphatase 2, fructose-bisphosphatase 2, Rae-30 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatase
- fructose-bisphosphatase
- protein binding
- FIG
- identical protein binding
- Fructose-1-6-bisphosphatase, C-terminal domain
Pathways
Biological processes and signaling networks where the Fbp2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatomegaly
- diabetes mellitus
- childhood-onset remitting leukodystrophy
- dermatomyositis
- amyotrophic lateral sclerosis
- hepatic injury
regulates
- D-glucose
- lactic acid
- GCK
- insulin
- pyruvic acid
- fructose-1-phosphate
role in cell
- production in
- glycolysis in
- accumulation in
- gluconeogenesis in
- utilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- sucrose biosynthetic process
- fructose 6-phosphate metabolic process
- fructose metabolic process
- fructose 1,6-bisphosphate metabolic process
Cellular Component
Where in the cell the gene product is active
- Z disc
- nucleus
- extracellular vesicular exosome
- anchoring junction
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- fructose 1,6-bisphosphate 1-phosphatase activity