Nudt5 Gene Summary [Rat]
Predicted to enable several functions, including magnesium ion binding activity; protein homodimerization activity; and pyrophosphatase activity. Predicted to be involved in D-ribose catabolic process; chromatin remodeling; and nucleoside phosphate metabolic process. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Predicted to be active in nucleus. Orthologous to human NUDT5 (nudix hydrolase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nudt5 |
| Official Name | nudix hydrolase 5 [Source:RGD Symbol;Acc:1359284] |
| Ensembl ID | ENSRNOG00000017741 |
| Bio databases IDs | |
| Aliases | nudix hydrolase 5 |
| Synonyms | ADP-sugar pyrophosphatase, hNUDT5, nudix hydrolase 5, YSA1, YSA1H, YSAH1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nudt5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-diphosphatase
- nucleotidyltransferase
- nudix-type nucleoside diphosphatase, YffH/AdpP family
- protein binding
- magnesium ion binding
- identical protein binding
- NUDIX domain
- ADP-sugar diphosphatase
- phosphatase
- protein homodimerization
- snoRNA binding
- ADPribose diphosphatase
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- periodontitis
- hypothyroidism
- asthma
regulates
- ADP-D-ribose
- nucleic acid component or derivative
- O-acetyl-ADP-ribose
- AMP
- D-ribose-5-phosphate
- ADP-D-mannose
- ribonucleoside diphosphate
- ribose
role in cell
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nudt5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- nucleobase-containing small molecule metabolic process
- ribose phosphate metabolic process
- ribonucleoside diphosphate catabolic process
- D-ribose catabolic process
- nucleoside phosphate metabolic process
- nucleotide metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- nucleotidyltransferase activity
- identical protein binding
- protein homodimerization activity
- protein binding
- snoRNA binding
- ADP-ribose diphosphatase activity
- ADP-sugar diphosphatase activity