Slc27a1 Gene Summary [Rat]
Predicted to enable several functions, including fatty acid-CoA ligase activity; icosanoid transmembrane transporter activity; and monocarboxylic acid transmembrane transporter activity. Predicted to be involved in several processes, including glucose import in response to insulin stimulus; lipid transport across blood-brain barrier; and monocarboxylic acid transport. Predicted to act upstream of or within several processes, including adiponectin-activated signaling pathway; positive regulation of heat generation; and response to insulin. Located in caveola and mitochondrial inner membrane. Biomarker of familial hyperlipidemia; glucose intolerance; hyperinsulinism; myocardial infarction; and obesity. Orthologous to human SLC27A1 (solute carrier family 27 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc27a1 |
| Official Name | solute carrier family 27 member 1 [Source:RGD Symbol;Acc:620927] |
| Ensembl ID | ENSRNOG00000018170 |
| Bio databases IDs | |
| Aliases | solute carrier family 27 member 1 |
| Synonyms | ACSVL5, FATP, FATP-1, solute carrier family 27 (fatty acid transporter), member 1, solute carrier family 27 member 1, Vlc27a1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc27a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- efflux permease
- fatty acid transporter
- Adenylate forming domain, Class I superfamily
- protein binding
- biotin transporter
- identical protein binding
- lipid transporter
- protein kinase activator
- fatty-acid ligase
- long-chain-fatty-acid-CoA ligase
- long-chain fatty acid transporter
- benzoate-CoA ligase family
- AMP-binding enzyme
- CoA-ligase
- AMP-binding enzyme C-terminal domain
- amino acid adenylation domain
- transporter
Pathways
Biological processes and signaling networks where the Slc27a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- obesity
- insulin resistance
- proximal tubular toxicity
- Huntington disease
- diastolic dysfunction
- breast carcinoma
- systemic lupus erythematosus
regulates
- lipid
- Ca2+
- D-glucose
- lignoceric acid
- fatty acid
- MYH7
- long chain fatty acid
- palmitic acid
- diacylglycerol
- acetate
role in cell
- differentiation
- expansion
- length
- oxidation in
- esterification in
- relaxation in
- calcium sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum fraction
- detergent-soluble membrane fractions
- membrane fraction
- intracellular membranes
- cellular membrane
- vesicles
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
- caveolae
- basal membrane
- mitochondrial inner membrane
- sarcolemma
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc27a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid import
- phosphatidylinositol biosynthetic process
- phosphatidylglycerol biosynthetic process
- phosphatidylcholine biosynthetic process
- negative regulation of phospholipid biosynthetic process
- phosphatidic acid biosynthetic process
- phosphatidylserine biosynthetic process
- response to cold
- phosphatidylethanolamine biosynthetic process
- long-chain fatty acid metabolic process
- glucose import in response to insulin stimulus
- long-chain fatty acid transport
- medium-chain fatty acid transport
- positive regulation of triglyceride biosynthetic process
- positive regulation of heat generation
- adiponectin-mediated signaling pathway
- biotin transport
- plasma membrane long-chain fatty acid transport
- cardiolipin biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- basal plasma membrane
- membrane
- endoplasmic reticulum
- plasma membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- biotin transporter activity
- very long-chain fatty acid-CoA ligase activity
- fatty acid transporter activity
- identical protein binding
- protein binding
- protein serine/threonine kinase activator activity
- efflux transmembrane transporter activity
- arachidonate-CoA ligase activity
- long-chain fatty acid-CoA ligase activity
- long-chain fatty acid transporter activity