Gtf2h2 Gene Summary [Rat]
Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in several processes, including G protein-coupled receptor internalization; nucleotide-excision repair; and transcription initiation at RNA polymerase II promoter. Predicted to be located in nuclear speck. Predicted to be part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. Orthologous to several human genes including GTF2H2C (GTF2H2 family member C) and GTF2H2 (general transcription factor IIH subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gtf2h2 |
| Official Name | general transcription factor IIH subunit 2 [Source:RGD Symbol;Acc:1310499] |
| Ensembl ID | ENSRNOG00000018230 |
| Bio databases IDs | |
| Aliases | general transcription factor IIH subunit 2 |
| Synonyms | BTF2, BTF2-p44, general transcription factor IIH subunit 2, p44, T-BTF2P44, TFIIH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gtf2h2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TFIIH C1-like domain
- transcription regulator
- von Willebrand factor (vWF) type A domain
- transcription factor ssl1
- Ssl1-like
- vWFA
- von Willebrand factor type A domain
- protein binding
- general RNA polymerase II transcription factor
Pathways
Biological processes and signaling networks where the Gtf2h2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gtf2h2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleotide-excision repair
- transcription from RNA polymerase II promoter
- G-protein coupled receptor internalization
- response to UV
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- nuclear speck
- core TFIIH complex
- core TFIIH complex portion of holo TFIIH complex
- holo TFIIH complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- general RNA polymerase II transcription factor activity