Ercc2 Gene Summary [Rat]
Predicted to enable 5'-3' DNA helicase activity; damaged DNA binding activity; and protein-macromolecule adaptor activity. Involved in embryonic organ development and response to hypoxia. Part of transcription factor TFIIH core complex. Biomarker of asphyxia neonatorum. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; acquired immunodeficiency syndrome; carcinoma (multiple); hematologic cancer (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ercc2 |
| Official Name | ERCC excision repair 2, TFIIH core complex helicase subunit [Source:RGD Symbol;Acc:1309109] |
| Ensembl ID | ENSRNOG00000017753 |
| Bio databases IDs | |
| Aliases | ERCC excision repair 2, TFIIH core complex helicase subunit |
| Synonyms | COFS2, CXPD, EM9, ERCC excision repair 2, TFIIH core complex helicase subunit, excision repair cross-complementing rodent repair deficiency, complementation group 2, LOC100361160, LOC100364929, Mhdarco15, RCO015, TFIIH, TFIIH p80, TTD, TTD1, XPD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ercc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA repair helicase (rad3)
- protein binding activity, bridging
- helicase superfamily c-terminal domain
- iron-sulfur cluster domain
- enzyme
- protein binding
- Helical and beta-bridge domain
- DNA helicase
- p44 tfiih binding domain
- helicase C-terminal domain
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Ercc2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- neutropenia
- head and neck cancer
- colorectal carcinomagenesis
- epithelial cancer
- abdominal cancer
- epithelial neoplasia
- digestive system cancer
- cancer
- squamous cell cancer
role in cell
- apoptosis
- phosphorylation in
- proliferation
- synthesis in
- recruitment in
- maturation
- differentiation
- survival
- organization
- recognition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- spindle apparatus
- Cytoplasm
- cytosol
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ercc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- embryonic cleavage
- UV protection
- transcription elongation from RNA polymerase I promoter
- determination of adult lifespan
- post-embryonic development
- transcription-coupled nucleotide-excision repair
- transcription from RNA polymerase II promoter
- nucleotide-excision repair
- chromosome segregation
- transcription initiation from RNA polymerase II promoter
- spinal cord development
- erythrocyte maturation
- response to oxidative stress
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- response to hypoxia
- in utero embryonic development
- DNA duplex unwinding
- apoptotic process
- central nervous system myelin formation
- hair cell differentiation
- bone mineralization
- insulin-like growth factor receptor signaling pathway
- positive regulation of mitotic recombination
- hemopoietic stem cell differentiation
- embryonic organ development
- hair follicle maturation
- regulation of transcription from RNA polymerase II promoter
- signal transduction by p53 class mediator resulting in induction of apoptosis
- extracellular matrix organization
- hemopoietic stem cell proliferation
Cellular Component
Where in the cell the gene product is active
- MMXD complex
- nucleus
- transcription factor TFIID complex
- cytoplasm
- core TFIIH complex
- spindle
- cytosol
- holo TFIIH complex
- CAK-ERCC2 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA helicase activity
- protein binding
- metal ion binding
- 4 iron, 4 sulfur cluster binding
- protein binding, bridging
- damaged DNA binding
- 5'-3' DNA helicase activity