Cacna1e Gene Summary [Rat]
Enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in calcium ion import and regulation of synaptic vesicle exocytosis. Located in perikaryon. Part of voltage-gated calcium channel complex. Is active in GABA-ergic synapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 69. Orthologous to human CACNA1E (calcium voltage-gated channel subunit alpha1 E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacna1e |
| Official Name | calcium voltage-gated channel subunit alpha1 E [Source:RGD Symbol;Acc:2246] |
| Ensembl ID | ENSRNOG00000002863 |
| Bio databases IDs | |
| Aliases | calcium voltage-gated channel subunit alpha1 E |
| Synonyms | A430040I15, alpha1E, BII, Cac1e, CACH6, CACHA1E, CACNL1A6, Calcium Channel alpha1e, Calcium channel isoform alpha 1e7, Calcium channel isoform α 1e7, calcium channel, voltage-dependent, R type, alpha 1E subunit, calcium channel, voltage-dependent, R type, α 1E subunit, calcium voltage-gated channel subunit alpha1 E, Cav2.3, Cchra1, DEE69, EIEE69, gm139, LOC103690332, Vdcc α 1e |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cacna1e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- Voltage-dependent L-type calcium channel, IQ-associated
- Voltage gated calcium channel IQ domain
- Ion transport protein
- low voltage-gated calcium channel
- protein binding
- voltage-gated ion channel
- ion channel
- Polycystin cation channel
- cation channel
Pathways
Biological processes and signaling networks where the Cacna1e gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Androgen Signaling
- Calcium Signaling
- Cardiac β-adrenergic Signaling
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Maturity Onset Diabetes of Young (MODY) Signaling
- Netrin Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- nNOS Signaling in Skeletal Muscle Cells
- PKCθ Signaling in T Lymphocytes
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- Ohtahara syndrome
- hereditary disorder
- amblyopia
- Parkinson disease
- neuroticism
- developmental epileptic encephalopathy
- early infantile epileptic encephalopathy type 69
- Alzheimer disease
- weight gain
role in cell
- exocytosis
- number
- motility
- function
- transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- inhibitory bouton
- cell surface
- postsynaptic region
- cellular membrane
- flagella
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- sperm head
- dendritic spines
- synaptic vesicles
- neuromuscular junctions
- synapse
- perikaryon
- dendrites
- postsynaptic density
- presynaptic terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cacna1e gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission
Cellular Component
Where in the cell the gene product is active
- voltage-gated calcium channel complex
- neuronal cell body
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- high voltage-gated calcium channel activity
- calcium ion binding
- voltage-gated cation channel activity
- voltage-gated calcium channel activity