Fig4 Gene Summary [Rat]
Enables phosphatidylinositol bisphosphate phosphatase activity; phosphatidylinositol-3-phosphate phosphatase activity; and phosphatidylinositol-4-phosphate phosphatase activity. Involved in positive regulation of neuron projection development. Located in recycling endosome. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4J; Yunis-Varon syndrome; amyotrophic lateral sclerosis type 11; and bilateral parasagittal parieto-occipital polymicrogyria. Orthologous to human FIG4 (FIG4 phosphoinositide 5-phosphatase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fig4 |
| Official Name | FIG4 phosphoinositide 5-phosphatase [Source:RGD Symbol;Acc:1311375] |
| Ensembl ID | ENSRNOG00000000312 |
| Bio databases IDs | |
| Aliases | FIG4 phosphoinositide 5-phosphatase |
| Synonyms | A530089I17Rik, ALS11, BOP, BTOP, CMT4J, dJ249I4.1, FIG4 phosphoinositide 5-phosphatase, KIAA0274, RGD1311375, SAC3, YVS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fig4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol-3-phosphatase
- phosphatase
- enzyme
- protein binding
- SacI homology domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- obesity
- Charcot-Marie-Tooth disease type 4j
- Charcot-Marie-Tooth disease type 4
- hereditary disorder
- chronic lymphocytic leukemia
- Yunis-Varon Syndrome
- amyotrophic lateral sclerosis type 11
- bilateral occipital polymicrogyria
- Charcot-Marie-Tooth disease
regulated by
- VAC14
- insulin
- cycloheximide
- 26S proteasome
role in cell
- binding in
- loss
- development
- assembly
- swelling
- organization
- aggregation in
- mislocalization in
- enlargement
- enlargement in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular membrane-bounded organelle
- perinuclear region
- intracellular membranes
- Plasma Membrane
- lipid droplets
- cytosol
- Golgi membrane
- endosomal membrane
- recycling endosomes
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fig4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- locomotory behavior
- vacuole organization
- pigmentation
- phosphatidylinositol-3-phosphate biosynthetic process
- myelin assembly
- phosphatidylinositol biosynthetic process
- neuron development
- negative regulation of myelination
- phosphatidylinositol dephosphorylation
Cellular Component
Where in the cell the gene product is active
- lipid particle
- early endosome membrane
- late endosome membrane
- intracellular membrane-bounded organelle
- endosome membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
- protein binding
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
- phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity