Ampd3 Gene Summary [Rat]
Enables AMP deaminase activity. Predicted to be involved in erythrocyte homeostasis and purine ribonucleotide metabolic process. Predicted to act upstream of or within ADP metabolic process; ATP metabolic process; and energy homeostasis. Predicted to be active in cytosol. Orthologous to human AMPD3 (adenosine monophosphate deaminase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ampd3 |
| Official Name | adenosine monophosphate deaminase 3 [Source:RGD Symbol;Acc:2111] |
| Ensembl ID | ENSRNOG00000018262 |
| Bio databases IDs | |
| Aliases | adenosine monophosphate deaminase 3 |
| Synonyms | adenosine monophosphate deaminase 3, Amp3, Amp deaminase h-type |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ampd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AMP deaminase
- enzyme
- protein binding
- metallo-dependent_hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hypertension
- chronic obstructive pulmonary disease
- aortic valve calcification
- major depression
- amyotrophic lateral sclerosis
- colorectal cancer
- erythrocyte AMP deaminase deficiency
- bipolar disorder
- idiopathic scoliosis
regulates
- adenosine triphosphate
- IMP
- guanosine triphosphate
- AMP
- ADP
role in cell
- function
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ampd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- AMP catabolic process
- IMP salvage
- AMP metabolic process
- IMP biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- AMP deaminase activity
- protein binding
- metal ion binding