Ampd1 Gene Summary [Rat]
Enables AMP deaminase activity and myosin heavy chain binding activity. Involved in response to ATP. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congestive heart failure and coronary artery disease. Orthologous to human AMPD1 (adenosine monophosphate deaminase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ampd1 |
| Official Name | adenosine monophosphate deaminase 1 [Source:RGD Symbol;Acc:2109] |
| Ensembl ID | ENSRNOG00000018656 |
| Bio databases IDs | |
| Aliases | adenosine monophosphate deaminase 1 |
| Synonyms | adenosine monophosphate deaminase 1, AI553520, Ampd01, MAD, MADA, MMDD, RATAMPD01 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ampd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin binding
- AMP deaminase
- enzyme
- protein binding
- metallo-dependent_hydrolases
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ampd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- GMP salvage
- IMP salvage
- AMP metabolic process
- IMP biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- AMP deaminase activity
- identical protein binding
- protein binding
- metal ion binding