Ampd3 Gene Summary [Mouse]
This gene encodes a member of the adenosine and AMP deaminases family. The encoded protein is an AMP deaminase involved in nucleotide and energy metabolism in erythrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Details
| Type | Protein Coding |
| Official Symbol | Ampd3 |
| Official Name | adenosine monophosphate deaminase 3 [Source:MGI Symbol;Acc:MGI:1096344] |
| Ensembl ID | ENSMUSG00000005686 |
| Bio databases IDs | |
| Aliases | adenosine monophosphate deaminase 3 |
| Synonyms | adenosine monophosphate deaminase 3, Amp3, Amp deaminase h-type |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ampd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AMP deaminase
- enzyme
- protein binding
- metallo-dependent_hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hypertension
- chronic obstructive pulmonary disease
- aortic valve calcification
- major depression
- amyotrophic lateral sclerosis
- colorectal cancer
- erythrocyte AMP deaminase deficiency
- bipolar disorder
- idiopathic scoliosis
regulates
- adenosine triphosphate
- IMP
- guanosine triphosphate
- AMP
- ADP
role in cell
- function
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ampd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- AMP catabolic process
- IMP salvage
- AMP metabolic process
- IMP biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- AMP deaminase activity
- protein binding
- metal ion binding