Atf2 Gene Summary [Rat]
Enables cAMP response element binding activity. Involved in several processes, including amelogenesis; positive regulation of neuron apoptotic process; and regulation of transcription by RNA polymerase II. Part of CCAAT-binding activity factor complex. Used to study hypertension and transient cerebral ischemia. Biomarker of glaucoma and transient cerebral ischemia. Orthologous to human ATF2 (activating transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atf2 |
| Official Name | activating transcription factor 2 [Source:RGD Symbol;Acc:621862] |
| Ensembl ID | ENSRNOG00000001597 |
| Bio databases IDs | |
| Aliases | activating transcription factor 2 |
| Synonyms | activating transcription factor 2, CREB-2, CRE-BP, CRE-BP1, D130078H02Rik, HB16, LOC100047997, mXBP, Tg(Gzma-Klra1)7Wum, TREB7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone acetyltransferase domain
- transcription regulator
- cAMP response element binding protein binding
- transcription activation domain
- transcription factor binding
- leucine zipper domain
- chromatin binding
- Jnk-binding domain
- identical protein binding
- zDHHC ankyrin repeat binding domain
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- basic domain
- bZIP
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- histone acetyltransferase
- dimerization domain
- protein kinase binding
- DNA binding domain
- nucleic acid binding
- LRR-domain binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- binding protein
- double-stranded DNA binding
- protein homodimerization
- zinc finger domain
- transcription factor activity
- protein heterodimerization
- basic region leucin zipper
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Atf2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- ATM Signaling
- BMP signaling pathway
- Cardiomyocyte Differentiation via BMP Receptors
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Developing Neuron Pathway
- Estrogen-Dependent Breast Cancer Signaling
- FGF Signaling
- Gαs Signaling
- HGF Signaling
- Hypoxia Signaling in the Cardiovascular System
- LPS-stimulated MAPK Signaling
- Melanocyte Development and Pigmentation Signaling
- Neurotrophin/TRK Signaling
- P2Y Purinergic Receptor Signaling Pathway
- PCP pathway
- Prostate Cancer Signaling
- Renin-Angiotensin Signaling
- Role of IL-17A in Arthritis
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Role of PKR in Interferon Induction and Antiviral Response
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- anemia
- lymphomagenesis
- metastasis
- breast cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- cyanosis
- tumorigenesis
role in cell
- growth
- cell death
- expression in
- production in
- apoptosis
- cell viability
- proliferation
- activation in
- phosphorylation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cellular membrane
- mitochondrial outer membrane
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- detection of cell density
- vacuole organization
- outflow tract morphogenesis
- facial nucleus development
- cellular lipid metabolic process
- JNK cascade
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- hemopoietic progenitor cell differentiation
- white fat cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- NK T cell differentiation
- motor neuron apoptotic process
- in utero embryonic development
- liver development
- BMP signaling pathway
- intra-S DNA damage checkpoint
- mRNA transcription from RNA polymerase II promoter
- positive regulation of gene expression, epigenetic
- p38MAPK cascade
- neurofilament cytoskeleton organization
- response to osmotic stress
- abducens nucleus development
- brainstem development
- hypoglossal nucleus development
- regulation of transcription, DNA-dependent
- response to organic cyclic compound
- response to DNA damage stimulus
- adipose tissue development
- hepatocyte apoptotic process
- regulation of transcription from RNA polymerase II promoter
- positive regulation of transforming growth factor beta2 production
- protein import into nucleus
- positive regulation of gene expression
- growth plate cartilage chondrocyte differentiation
- positive regulation of protein phosphorylation
- growth plate cartilage chondrocyte proliferation
- cellular response to oxidative stress
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- cytoplasm
- mitochondrial outer membrane
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cAMP response element binding protein binding
- protein kinase binding
- identical protein binding
- cAMP response element binding
- protein homodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- H2B histone acetyltransferase activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- leucine zipper domain binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- histone acetyltransferase activity
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein heterodimerization activity
- metal ion binding
- H4 histone acetyltransferase activity