Cdh22 Gene Summary [Rat]
Predicted to enable beta-catenin binding activity and cadherin binding activity. Involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Orthologous to human CDH22 (cadherin 22). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdh22 |
| Official Name | cadherin 22 [Source:RGD Symbol;Acc:2321] |
| Ensembl ID | ENSRNOG00000018557 |
| Bio databases IDs | |
| Aliases | cadherin 22 |
| Synonyms | C20orf25, cadherin 22, dJ998H6.1, Pb-Cadherin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdh22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cadherin, Y-type LIR-motif
- cytoplasmic domain
- Cadherin repeat-like domain
Pathways
Biological processes and signaling networks where the Cdh22 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdh22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-dependent cell-cell adhesion
- cell-cell junction assembly
- adherens junction organization
- multicellular organismal development
- cell morphogenesis
- cell-cell adhesion mediated by cadherin
- homophilic cell adhesion
- cell migration
Cellular Component
Where in the cell the gene product is active
- adherens junction
- catenin complex
Molecular Function
What the gene product does at the molecular level
- cadherin binding
- calcium ion binding
- beta-catenin binding