Ctf1 Gene Summary [Rat]
Enables cytokine activity and leukemia inhibitory factor receptor binding activity. Involved in leukemia inhibitory factor signaling pathway and nervous system development. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Biomarker of hypertension and hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CTF1 (cardiotrophin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctf1 |
| Official Name | cardiotrophin 1 [Source:RGD Symbol;Acc:2442] |
| Ensembl ID | ENSRNOG00000018962 |
| Bio databases IDs | |
| Aliases | cardiotrophin 1 |
| Synonyms | CARDIOTROPHIN 1, CT-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ctf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- leukemia inhibitory factor receptor binding
- receptor binding domain
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Ctf1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- dilated cardiomyopathy
- colorectal cancer
- obesity
role in cell
- expression in
- cell death
- growth
- quantity
- apoptosis
- production in
- phosphorylation in
- proliferation
- lipolysis in
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ctf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- neuron differentiation
- positive regulation of cell proliferation
- cell-cell signaling
- cell surface receptor signaling pathway
- neuron development
- positive regulation of tyrosine phosphorylation of STAT protein
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity
- leukemia inhibitory factor receptor binding