Myh7b Gene Summary [Rat]
Predicted to enable actin filament binding activity and microfilament motor activity. Involved in regulation of CAMKK-AMPK signaling cascade; regulation of cardiac muscle cell contraction; and regulation of cytosolic calcium ion concentration. Predicted to be located in cardiac myofibril. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human MYH7B (myosin heavy chain 7B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myh7b |
| Official Name | myosin heavy chain 7B [Source:RGD Symbol;Acc:1307994] |
| Ensembl ID | ENSRNOG00000018997 |
| Bio databases IDs | |
| Aliases | myosin heavy chain 7B |
| Synonyms | lncMYH7b, LOC381400, MHC14, MYH14, myosin heavy chain 7B, myosin, heavy chain 7B, cardiac muscle, beta, myosin, heavy chain 7B, cardiac muscle, β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Myh7b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Synaptonemal complex protein 1 (SCP-1)
- Myosin N-terminal SH3-like domain
- helix-rich Mycoplasma protein
- Putative golgin subfamily A member 2-like protein 5
- Laminin Domain I
- chromosome segregation protein SMC, common bacterial type
- Tropomyosin
- HOOK protein coiled-coil region
- Crescentin protein
- Mitotic checkpoint protein
- chromosome segregation protein SMC, primarily archaeal type
- TPR/MLP1/MLP2-like protein
- exonuclease SbcC
- Weak chloroplast movement under blue light
- Tropomyosin like
- Myosin and Kinesin motor domain
- Hyaluronan mediated motility receptor N-terminal
- rad50
- Myosin tail
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Myosin head (motor domain)
- Alpha helical coiled-coil rod protein (HCR)
- RecF/RecN/SMC N terminal domain
- Growth-arrest specific micro-tubule binding
- Intermediate filament protein
- Myosin
- Apolipoprotein A1/A4/E domain
Pathways
Biological processes and signaling networks where the Myh7b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- Brugada syndrome
- familial hypertrophic cardiomyopathy type 1
- melanoma
- melanoma cancer
- non-melanoma skin cancer
regulates
role in cell
- morphology
- expression in
- synaptic strength
- sarcomere organization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myofilaments
- myofibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Myh7b gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- myosin II complex
- membrane
- myosin filament
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- protein binding
- microfilament motor activity