NEWGENE_1308624 Gene Summary [Rat]
Predicted to enable exo-alpha-sialidase activity. Predicted to be involved in several processes, including ganglioside catabolic process; glycoprotein catabolic process; and negative regulation of neuron projection development. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; mitochondrial membrane; and neuron projection. Predicted to be active in lysosome and membrane. Orthologous to human NEU4 (neuraminidase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | NEWGENE_1308624 |
| Official Name | sialidase 4 [Source:RGD Symbol;Acc:9204096] |
| Ensembl ID | ENSRNOG00000019031 |
| Bio databases IDs | |
| Aliases | sialidase 4 |
| Synonyms | 9330166I04, neuraminidase 4, NEWGENE 1308624, sialidase 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Newgene_1308624 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sialidases/neuraminidases
- Exo-alpha-sialidase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- dextran sodium sulfate-induced colitis
role in cell
- activation in
- outgrowth
- motility
- number
- formation
- growth
- development
- function
- formation in
- outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- lysosome
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- mitochondrial inner membrane
- lysosomal compartment
- growth cone
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Newgene_1308624 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein catabolic process
- negative regulation of neuron projection development
- oligosaccharide catabolic process
- ganglioside catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- membrane
- lysosomal lumen
- mitochondrial outer membrane
- neuron projection
- mitochondrial inner membrane
- plasma membrane
- lysosome
- organelle inner membrane
Molecular Function
What the gene product does at the molecular level
- exo-alpha-(2->6)-sialidase activity
- exo-alpha-(2->8)-sialidase activity
- protein binding
- exo-alpha-sialidase activity
- exo-alpha-(2->3)-sialidase activity