Alox15 Gene Summary [Rat]
Enables hepoxilin-epoxide hydrolase activity; hydroperoxy icosatetraenoate isomerase activity; and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in fatty acid metabolic process and positive regulation of heterotypic cell-cell adhesion. Located in cytosol. Biomarker of brain ischemia; congestive heart failure; and glomerulonephritis. Orthologous to human ALOX15 (arachidonate 15-lipoxygenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alox15 |
| Official Name | arachidonate 15-lipoxygenase [Source:RGD Symbol;Acc:70493] |
| Ensembl ID | ENSRNOG00000019183 |
| Bio databases IDs | |
| Aliases | arachidonate 15-lipoxygenase |
| Synonyms | 12/15 LO, 12/15-LOX, 12-Lipoxygenase, 12-LO, 12-LOX, 15-Lipoxygenase, 15-LOX, 15-LOX-1, Alox12, Alox12l, arachidonate 15-lipoxygenase, Arachidonate 5-lipoxygenase, L-12LO, L12lox, Leukocyte-type 12-lo |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Alox15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipoxygenase
- arachidonate 12-lipoxygenase
- phosphatidylinositol-4,5-bisphosphate binding
- intramolecular transferase activity, transferring hydroxy groups
- PLAT
- arachidonate 15-lipoxygenase
- hepoxilin-epoxide hydrolase
- iron ion binding
- enzyme
- Lipoxygenase homology 2 (beta barrel) domain
- potassium channel inhibitor
Pathways
Biological processes and signaling networks where the Alox15 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- insulin-dependent diabetes mellitus
- atherosclerosis
- diabetic nephropathy
- abdominal aortic aneurysm
- dextran sodium sulfate-induced colitis
- mechanical hypersensitivity
- renal fibrosis
- anemia
- TNBS-induced colitis
role in cell
- expression in
- migration
- hypertrophy
- phosphorylation in
- apoptosis
- adhesion
- generation in
- volume
- formation in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- cellular membrane
- Plasma Membrane
- endosomes
- Mitochondria
- lipid droplets
- cytosol
- cytoplasmic face of plasma membrane
- cytoplasmic droplets
- growth cone
- sarcolemma