Vamp1 Gene Summary [Rat]
Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in SNARE complex assembly; regulation of synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle priming. Located in terminal bouton. Is active in presynapse. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and spastic ataxia 1. Orthologous to human VAMP1 (vesicle associated membrane protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vamp1 |
| Official Name | vesicle-associated membrane protein 1 [Source:RGD Symbol;Acc:3948] |
| Ensembl ID | ENSRNOG00000019219 |
| Bio databases IDs | |
| Aliases | vesicle-associated membrane protein 1 |
| Synonyms | CMS25, lew, SAX1, SPAX1, SYB1, synaptobrevin 1, vesicle-associated membrane protein 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vamp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- SNARE motif
- Synaptobrevin
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- traumatic brain injury
- adenoma formation
- stroke
- presynaptic congenital myasthenic syndrome type 25
- spastic paraplegia
- cerebral palsy
- autosomal dominant spastic ataxia type 1
- muscle spasticity
- chronic sialorrhea
role in cell
- expression in
- quantity
- size
- density
- exocytosis by
- priming
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- azurophilic granule membrane
- glutaminergic synapse
- fibrillar organelles
- presynaptic regions
- cell surface
- cellular membrane
- Plasma Membrane
- endosomes
- Golgi Apparatus
- Mitochondria
- tertiary granule membrane
- specific granule membrane
- cytosol
- vesicle membrane
- synaptic vesicles
- neuromuscular junctions
- multivesicular bodies
- azurophil granules
- specific granules
- tertiary granules
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vamp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle fusion
- SNARE complex assembly
Cellular Component
Where in the cell the gene product is active
- cytosol
- SNARE complex
- synaptic vesicle membrane
- mitochondrial outer membrane
- neuron projection
- azurophil granule membrane
- plasma membrane
- tertiary granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin binding
- SNAP receptor activity